All-DNA finite-state automata with finite memory.
basic_science · Level V
Where this comes from
- Record sourced from PubMed, PMID 21135212.
- Also identified by DOI 10.1073/pnas.1015858107 and PMC identifier 3009826.
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Abstract
Biomolecular logic devices can be applied for sensing and nano-medicine. We built three DNA tweezers that are activated by the inputs H(+)/OH(-); ; nucleic acid linker/complementary antilinker to yield a 16-states finite-state automaton. The outputs of the automata are the configuration of the respective tweezers (opened or closed) determined by observing fluorescence from a fluorophore/quencher pair at the end of the arms of the tweezers. The system exhibits a memory because each current state and output depend not only on the source configuration but also on past states and inputs.
Medical subject headings
- Computers, Molecular
- DNA