Evolutionary dynamics of cancer prevention.
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- Record sourced from PubMed, PMID 21137109.
- Also identified by DOI 10.1038/nrc2892 and PMC identifier 3744108.
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Abstract
Multicellular organisms must evolve mechanisms to suppress cancer formation prior to reproduction, and we propose that the organizational structure of normal epithelium is one such strategy. Understanding evolved host cancer suppression mechanisms is essential to defining the first steps of carcinogenesis and developing rational cancer prevention strategies.
Medical subject headings
- Biological Evolution
- Cell Transformation, Neoplastic
- Epithelium
- Neoplasms
- Stem Cells