Insulin signaling: inositol phosphates get into the Akt.
basic_science · Level V
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- Record sourced from PubMed, PMID 21145450.
- Also identified by DOI 10.1016/j.cell.2010.11.040 and PMC identifier 3693466.
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Abstract
An acute but transient response to insulin is essential for glucose homeostasis in mammals. Chakraborty et al. (2010) uncover a new feedback mechanism regulating insulin signaling. They show that the inositol pyrophosphate IP7, which is produced in response to insulin, inhibits the Akt kinase, a primary effector of insulin signaling.