Lipid trafficking sans vesicles: where, why, how?
review · Level V
Where this comes from
- Record sourced from PubMed, PMID 21145454.
- Also identified by DOI 10.1016/j.cell.2010.11.031 and PMC identifier 3004474.
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Abstract
Eukaryotic cells possess a remarkable diversity of lipids, which distribute among cellular membranes by well-characterized vesicle trafficking pathways. However, transport of lipids by alternate, or "nonvesicular," routes is also critical for lipid synthesis, metabolism, and proper membrane partitioning. In the past few years, considerable progress has been made in characterizing the mechanisms of nonvesicular lipid transport and how it may go awry in particular diseases, but many fundamental questions remain for this rising field.
Medical subject headings
- Carrier Proteins
- Eukaryotic Cells
- Lipid Metabolism