Dual resistance to adamantanes and oseltamivir among seasonal influenza A(H1N1) viruses: 2008-2010.
other · Level V
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- Record sourced from PubMed, PMID 21148491.
- Also identified by DOI 10.1093/infdis/jiq005 and PMC identifier 3086447.
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Abstract
Two distinct genetic clades of seasonal influenza A(H1N1) viruses have cocirculated in the recent seasons: clade 2B oseltamivir-resistant and adamantane-susceptible viruses, and clade 2C viruses that are resistant to adamantanes and susceptible to oseltamivir. We tested seasonal influenza A(H1N1) viruses collected in 2008-2010 from the United States and globally for resistance to antivirals approved by the Food and Drug Administration. We report 28 viruses with both adamantane and oseltamivir (dual) resistance from 5 countries belonging to 4 distinct genotypes. Because of limited options for antiviral treatment, emergence of dual-resistant influenza viruses poses a public health concern, and their circulation needs to be closely monitored.
Medical subject headings
- Adamantane
- Antiviral Agents
- Drug Resistance, Multiple, Viral
- Influenza A Virus, H1N1 Subtype
- Influenza, Human
- Oseltamivir