Evidence of person-to-person transmission of oseltamivir-resistant pandemic influenza A(H1N1) 2009 virus in a hematology unit.
case_series · Level IV
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- Record sourced from PubMed, PMID 21148492.
- Also identified by DOI 10.1093/infdis/jiq007 and PMC identifier 3086444.
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Abstract
We describe the first confirmed person-to-person transmission of oseltamivir-resistant pandemic influenza A(H1N1) 2009 virus that occurred in a hematology unit in the United Kingdom. Eleven cases of (H1N1) 2009 virus infection were identified, of which, ten were related as shown by sequence analysis of the hemagglutinin and neuraminidase genes. H275Y analysis demonstrated that 8 of 10 case patients had oseltamivir-resistant virus, with 4 of 8 case patients infected by direct transmission of resistant virus. Zanamivir should be considered as first-line therapy for influenza in patients with lymphopenic hematological conditions and uptake of influenza vaccination encouraged to further reduce the number of susceptible individuals.
Medical subject headings
- Antiviral Agents
- Drug Resistance, Viral
- Influenza A Virus, H1N1 Subtype
- Influenza, Human
- Oseltamivir