Folic acid conjugates for nuclear imaging of folate receptor-positive cancer.
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- Record sourced from PubMed, PMID 21149477.
- Also identified by DOI 10.2967/jnumed.110.076018.
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Abstract
The folate receptor (FR) is overexpressed on a variety of tumor types, whereas its distribution in normal tissues and organs is highly limited. Exploration of the utility of the FR revealed its promising potential for targeting with folate-based radiopharmaceuticals. Herein, we report the principle of the FR-targeting strategy and summarize the development of several folic acid radioconjugates useful for SPECT and PET of cancer diseases. The potential applicability of folate radiopharmaceuticals for FR-targeted radionuclide therapy is also discussed.
Medical subject headings
- Folate Receptors, GPI-Anchored
- Folic Acid
- Neoplasms
- Positron-Emission Tomography
- Radiopharmaceuticals
- Tomography, Emission-Computed, Single-Photon