Through a glass darkly: salt transport by the distal tubule.
editorial · Level V
Where this comes from
- Record sourced from PubMed, PMID 21157456.
- Also identified by DOI 10.1038/ki.2010.400 and PMC identifier 3729292.
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Abstract
The distal convoluted tubule (DCT) plays a central role in blood pressure and potassium homeostasis, as evidenced by diseases that occur when its function is modified. The paper by van der Lubbe and colleagues makes clear that angiotensin II itself increases the activity and abundance of the thiazide-sensitive Na-Cl cotransporter (NCC), independent of changes in circulating aldosterone. This Commentary provides additional perspective on that work.
Medical subject headings
- Kidney Tubules, Distal
- Sodium Chloride
- Sodium Chloride Symporters