20-HETE in acute kidney injury.
editorial · Level V
Where this comes from
- Record sourced from PubMed, PMID 21157458.
- Also identified by DOI 10.1038/ki.2010.396 and PMC identifier 3146060.
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Abstract
Ischemia/reperfusion injury (IRI) is a common cause of acute kidney injury (AKI) that is associated with a patient mortality of up to 50%. Currently there are not effective pharmacologic therapies for AKI. This Commentary highlights recent evidence indicating that 20-HETE plays an important role in IRI and that drugs that target this pathway have potential as therapeutic agents for AKI.
Medical subject headings
- Acute Kidney Injury
- Hydroxyeicosatetraenoic Acids
- Reperfusion Injury