Toxicity of cetuximab versus cisplatin concurrent with radiotherapy in locally advanced head and neck squamous cell cancer (LAHNSCC).
retrospective_cohort · Level III
Where this comes from
- Record sourced from PubMed, PMID 21159400.
- Also identified by DOI 10.1016/j.radonc.2010.11.009.
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Abstract
We retrospectively reviewed acute toxicity with cetuximab and radiotherapy, comparing it with a matched cisplatin group. The cetuximab group experienced significantly more toxicity--grade ≥3 oral mucositis (p=0.014), skin dermatitis (p=0.0004), ≥10% weight loss (p=0.03), and enteral feeding requirement (p=0.05). This finding of enhanced toxicity is similar to recent publications.
Medical subject headings
- Antibodies, Monoclonal
- Antineoplastic Agents
- Cisplatin