Candidate gene association study of magnetic resonance imaging-based hip osteoarthritis (OA): evidence for COL9A2 gene as a common predisposing factor for hip OA and lumbar disc degeneration.
case_control · Level III
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- Record sourced from PubMed, PMID 21159828.
- Also identified by DOI 10.3899/jrheum.100080.
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Abstract
To study whether gene variants associated with lumbar disc degeneration (LDD) phenotypes are also associated with hip osteoarthritis (OA). Magnetic resonance imaging (MRI)-based hip OA changes for 345 twins were assessed and 99 single-nucleotide polymorphisms (SNP) were analyzed. Variants in the COL9A2 (rs7533552, p = 0.0025) and COL10A1 (rs568725, p = 0.002) genes showed association with hip OA. The associating G allele in COL9A2 changes a glutamine to arginine or to tryptophan and may predispose to both hip OA and LDD, making it a candidate for degenerative connective tissue diseases.
Medical subject headings
- Collagen Type IX
- Genetic Predisposition to Disease
- Intervertebral Disc Degeneration
- Lumbar Vertebrae
- Osteoarthritis, Hip
- Polymorphism, Single Nucleotide