The functional polymorphism 844 A>G in FcαRI (CD89) does not contribute to systemic sclerosis or rheumatoid arthritis susceptibility.
case_control · Level III
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- Record sourced from PubMed, PMID 21159834.
- Also identified by DOI 10.3899/jrheum.100427.
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Abstract
To investigate the role of the Fc(α)RI 844 A>G functional polymorphism in the genetic predisposition to rheumatoid arthritis (RA) and systemic sclerosis (SSc) susceptibility. The study population was composed of 1401 patients with SSc, 642 patients with RA, and 1317 healthy controls. The Fc(α)RI (CD89) single-nucleotide polymorphism rs16986050 was genotyped by pyrosequencing. We observed no significant deviation of the genotype and allele frequencies in RA and SSc compared to controls. A metaanalysis and a recessive and dominant model yielded similar negative results. Our data show that the Fc(α)RI 844 A>G polymorphism is not associated with SSc or RA susceptibility.
Medical subject headings
- Antigens, CD
- Arthritis, Rheumatoid
- Genetic Predisposition to Disease
- Polymorphism, Single Nucleotide
- Receptors, Fc
- Scleroderma, Systemic