New bioinspired membrane made of a biological ion channel confined into the cylindrical nanopore of a solid-state polymer.
basic_science · Level V
Where this comes from
- Record sourced from PubMed, PMID 21174453.
- Also identified by DOI 10.1021/nl103841m.
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Abstract
A hybrid nanoporous membrane made of a solid-state polymeric thin film in which an ion channel is confined is realized. The primary and extremely encouraging results obtained by confocal fluorescence spectroscopy and ion diffusion measurement demonstrate respectively that (i) the considered ion channel, that is, Gramicidin-A, can be confined selectively inside the nanopores and (ii) the ionic permeability of the membrane is enhanced. Atomistic molecular simulations are also reported and fruitfully compared to the experimental findings.
Medical subject headings
- Biomimetic Materials
- Gramicidin
- Ion Channels
- Membranes, Artificial
- Nanostructures