Normalization of FoxP3(+) regulatory T cells in response to effective antiretroviral therapy.
prospective_cohort · Level II
Where this comes from
- Record sourced from PubMed, PMID 21177309.
- Also identified by DOI 10.1093/infdis/jiq073 and PMC identifier 3071220.
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Abstract
Regulatory T cells (Tregs) blunt uncontrolled immune responses. In advanced human immunodeficiency virus (HIV) infection, the total number of Tregs is decreased, but the proportion of T cells with a regulatory phenotype is highly variable. We studied CD4(+)CD25(+)FoxP3(+) T cells from patients successfully treated with combination antiretroviral therapy (ART). The proportion of CD4(+)CD25(+)FoxP3(+) cells transiently increased and then decreased from a median of 13% at baseline to 5.1% at 48 weeks, similar to values in normal subjects. These data suggest that with effective therapy, the regulatory cell numbers normalize, and that the inflammatory signals driving their production may also abate.
Medical subject headings
- Anti-HIV Agents
- Antiretroviral Therapy, Highly Active
- Forkhead Transcription Factors
- HIV Infections
- T-Lymphocytes, Regulatory