Uveal malignant melanoma and optic nerve glioma in von Recklinghausen's neurofibromatosis.
case_report · Level V
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- Record sourced from PubMed, PMID 2117971.
- Also identified by PMC identifier 1042186.
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Abstract
A case of uveal malignant melanoma and contralateral optic nerve glioma is described in a 53-year-old Caucasian male with multiple uveal melanocytic hamartomas and neurofibromatosis. The eye was enucleated, and histologically the melanoma was found to consist of 70% epithelioid cells, with many bizarre, multinucleated forms. CT scan demonstrated a non-enhancing, fusiform enlargement of the contralateral optic nerve with enlargement of the optic canal and intracranial extension. This combination of tumours has not previously been reported in a patient with neurofibromatosis and serves to emphasise the common neuroectodermal origin of tumours in this autosomal dominant condition.
Medical subject headings
- Cranial Nerve Neoplasms
- Glioma
- Melanoma
- Neoplasms, Multiple Primary
- Neurofibromatosis 1
- Optic Nerve Diseases
- Uveal Neoplasms