The effect of hemodialysis and hemoperfusion on serum valproic acid concentration.
case_report · Level V
Where this comes from
- Record sourced from PubMed, PMID 2118241.
- No licence information is recorded for this record.
- Because redistribution is not established, this page shows the abstract only. Follow the links below for the full text.
Abstract
We report a patient with dialysis-induced encephalopathy who was taking divalproex sodium for a seizure disorder. Her serum valproic acid concentration appeared to be in the low therapeutic range at 54 mg/l yet she continued to have seizure activity. The elimination half-life and apparent clearance of valproic acid were the same for both a dialysis and nondialysis day, indicating that hemodialysis/hemoperfusion has little effect on the overall removal of valproic acid from the body.
Medical subject headings
- Hemoperfusion
- Renal Dialysis
- Valproic Acid