Duchenne muscular dystrophy models show their age.
basic_science · Level V
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- Record sourced from PubMed, PMID 21183068.
- Also identified by DOI 10.1016/j.cell.2010.12.005 and PMC identifier 3038548.
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Abstract
The lack of appropriate animal models has hampered efforts to develop therapies for Duchenne muscular dystrophy (DMD). A new mouse model lacking both dystrophin and telomerase (Sacco et al., 2010) closely mimics the pathological progression of human DMD and shows that muscle stem cell activity is a key determinant of disease severity.