Wnt signaling: multivesicular bodies hold GSK3 captive.
basic_science · Level V
Where this comes from
- Record sourced from PubMed, PMID 21183070.
- Also identified by DOI 10.1016/j.cell.2010.12.003.
- No licence information is recorded for this record.
- Because redistribution is not established, this page shows the abstract only. Follow the links below for the full text.
Abstract
Two key events in Wnt signal transduction, receptor endocytosis and inactivation of Glycogen Synthase Kinase 3 (GSK3), remain incompletely understood. Taelman et al. (2010) discover that Wnt signaling inactivates GSK3 by sequestering the enzyme in multivesicular bodies, thus linking these two events and providing a new framework for understanding Wnt signaling.