Genes for tryptophan biosynthesis in the archaebacterium Haloferax volcanii.

Lam, W L; Cohen, A; Tsouluhas, D; Doolittle, W F · Proc Natl Acad Sci U S A · 1990

other · Level V

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Abstract

Recent technical advances permit direct genetic approaches for isolating genes and mapping auxotrophic mutations in the halophilic archaebacterium (Archaea) Haloferax volcanii. Twenty-nine mutations in tryptophan biosynthesis mapped to two separate chromosomal locations. DNA sequencing of one gene cluster shows a unique gene order (trpCBA) and unusual potential secondary structures in the 5'-flanking region.

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