A new role for a metabolic star: AMP-activated protein kinase stimulates fat absorption.
basic_science · Level V
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- Record sourced from PubMed, PMID 21195340.
- Also identified by DOI 10.1016/j.cmet.2010.12.009.
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Abstract
AMPK is a kinase involved in cell energy homeostasis. In this issue of Cell Metabolism, Chopra and colleagues (2011) reveal a new function of AMPK in stimulating fat absorption. AMPK enhances the expression of the bile acid transporter, BSEP, by activating the coactivator SRC-2, thus promoting bile acid secretion.