The tumor suppressor LKB1 emerges as a critical factor in hematopoietic stem cell biology.
Where this comes from
- Record sourced from PubMed, PMID 21195344.
- Also identified by DOI 10.1016/j.cmet.2010.12.015.
- No licence information is recorded for this record.
- Because redistribution is not established, this page shows the abstract only. Follow the links below for the full text.
Abstract
How cellular metabolism regulates stem cell function is poorly understood but is an emerging field of study. In a recent issue of Nature, three independent groups demonstrate that LKB1 promotes hematopoietic stem cell (HSC) quiescence and metabolic homeostasis. Surprisingly, these effects on HSCs occur independently of AMPK/mTOR and FoxO signaling.