Long intergenic noncoding RNAs: new links in cancer progression.
review · Level V
Where this comes from
- Record sourced from PubMed, PMID 21199792.
- Also identified by DOI 10.1158/0008-5472.CAN-10-2483 and PMC identifier 3057914.
- No licence information is recorded for this record.
- Because redistribution is not established, this page shows the abstract only. Follow the links below for the full text.
Abstract
The process of cancer metastasis involves a series of sequential and complex steps. Here we give a perspective on recent results regarding noncoding transcription in cancer progression, focusing on the emerging role of long intergenic noncoding RNAs (lincRNAs). LincRNAs target chromatin modification complexes or RNA-binding proteins to alter gene expression programs. Similarly to miRNAs, lincRNAs exhibit distinct gene expression patterns in primary tumors and metastases. We discuss how lincRNAs can be used for cancer diagnosis and prognosis and serve as potential therapeutic targets.
Medical subject headings
- Neoplasms
- RNA, Untranslated