Background-free detection of single 5 nm nanoparticles through interferometric cross-polarization microscopy.
basic_science · Level V
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- Record sourced from PubMed, PMID 21204579.
- Also identified by DOI 10.1021/nl1034489.
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Abstract
Metal nanoparticles play a key role in sensing and imaging. Here we demonstrate the detection of metal particles down to 5 nm in size with a signal-to-noise ratio of ∼7 using interferometric cross-polarization microscopy at ultralow excitation powers (∼1 μW) compatible with single molecule detection. The method is background-free and induces no heating as it operates far from plasmonic resonance. The combination of unlimited observation time and protein-sized metal nanoparticles has great potential for biophysical applications.
Medical subject headings
- Materials Testing
- Microscopy, Interference
- Microscopy, Polarization
- Nanostructures