Molecular targeting of neural cancer stem cells: TTAGGG, you're it!
editorial · Level V
Where this comes from
- Record sourced from PubMed, PMID 21208901.
- Also identified by DOI 10.1158/1078-0432.CCR-10-2686 and PMC identifier 3099413.
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Abstract
Telomerase is an important mechanism by which cancers escape replicative senescence. In neural tumors, cancer stem cells express telomerase, suggesting that this may explain their preferential tumorigenesis. Oligonucleotide telomerase targeting selectively disrupts cancer stem cell growth through the induction of differentiation, adding to the armamentarium of anticancer stem cell therapies.
Medical subject headings
- Glioma
- Neoplastic Stem Cells
- Neural Stem Cells
- Neuroblastoma
- Telomerase
- Telomere