Autologous extracellular matrix scaffolds for tissue engineering.
basic_science · Level V
Where this comes from
- Record sourced from PubMed, PMID 21211834.
- Also identified by DOI 10.1016/j.biomaterials.2010.12.016.
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Abstract
Development of autologous scaffolds has been highly desired for implantation without eliciting adverse inflammatory and immune responses. However, it has been difficult to obtain autologous scaffolds by tissue decellularization because of the restricted availability of autologous donor tissues from a patient. Here we report a method to prepare autologous extracellular matrix (aECM) scaffolds by combining culture of autologous cells in a three-dimensional template, decellularization, and template removal. The aECM scaffolds showed excellent biocompatibility when implanted. We anticipate that "Full Autologous Tissue Engineering" can be realized to minimize undesirable host tissue responses by culturing the patient's own cells in an aECM scaffold.
Medical subject headings
- Extracellular Matrix
- Tissue Engineering
- Tissue Scaffolds