Cardiopoietic factors: extracellular signals for cardiac lineage commitment.
basic_science · Level V
Where this comes from
- Record sourced from PubMed, PMID 21212394.
- Also identified by DOI 10.1161/CIRCRESAHA.110.223792.
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Abstract
Cardiac muscle creation during embryogenesis requires extracellular instructive signals that are regulated precisely in time and space, intersecting with intracellular genetic programs that confer or fashion the ability of the cells to respond. Unmasking the essential signals for cardiac lineage decisions has paramount importance for cardiac development and regenerative medicine, including the directed differentiation of progenitor and stem cells to a cardiac muscle fate.
Medical subject headings
- Cell Differentiation
- Intercellular Signaling Peptides and Proteins
- Myocardium
- Signal Transduction
- Stem Cells