Detection of circulating tumor cells in human peripheral blood using surface-enhanced Raman scattering nanoparticles.
case_series · Level IV
Where this comes from
- Record sourced from PubMed, PMID 21212408.
- Also identified by DOI 10.1158/0008-5472.CAN-10-3069 and PMC identifier 3079317.
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Abstract
The detection and characterization of circulating tumor cells (CTC) holds great promise for personalizing medicine and optimizing systemic therapy. However, low specificity, low sensitivity, and the time consuming nature of current approaches have impeded clinical adoption. Here we report a new method using surface-enhanced Raman spectroscopy (SERS) to directly measure targeted CTCs in the presence of white blood cells. SERS nanoparticles with epidermal growth factor peptide as a targeting ligand have successfully identified CTCs in the peripheral blood of 19 patients with squamous cell carcinoma of the head and neck (SCCHN), with a range of 1 to 720 CTCs per milliliter of whole blood. Our technique may provide an important new clinical tool for management of patients with SCCHN and other cancers.
Medical subject headings
- Carcinoma, Squamous Cell
- Head and Neck Neoplasms
- Nanoparticles
- Neoplastic Cells, Circulating
- Spectrum Analysis, Raman