Cancer genomes evolve by pulverizing single chromosomes.
editorial · Level V
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- Record sourced from PubMed, PMID 21215363.
- Also identified by DOI 10.1016/j.cell.2010.12.025.
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Abstract
A report in this issue describes "chromothripsis," a new mechanism for genetic instability in cancer cells. Chromothripsis appears to be a cataclysmic event in which a single chromosome is fragmented and then reassembled. The phenomenon raises important questions of how chromosome rearrangements can be confined to defined genome segments.