Mitochondrial stress signals revise an old aging theory.
editorial · Level V
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- Record sourced from PubMed, PMID 21215364.
- Also identified by DOI 10.1016/j.cell.2010.12.023.
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Abstract
In this issue, Durieux et al. (2011) describe a tissue-specific signal, originating from mitochondria, that acts cell non-autonomously to regulate life span in the nematode, C. elegans. This new finding provides a first step toward resolving the relative contributions of mitochondrial free radical damage and signaling mechanisms in aging.