Epigenetics in alternative pre-mRNA splicing.
review · Level V
Where this comes from
- Record sourced from PubMed, PMID 21215366.
- Also identified by DOI 10.1016/j.cell.2010.11.056 and PMC identifier 3038581.
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Abstract
Alternative splicing plays critical roles in differentiation, development, and disease and is a major source for protein diversity in higher eukaryotes. Analysis of alternative splicing regulation has traditionally focused on RNA sequence elements and their associated splicing factors, but recent provocative studies point to a key function of chromatin structure and histone modifications in alternative splicing regulation. These insights suggest that epigenetic regulation determines not only what parts of the genome are expressed but also how they are spliced.
Medical subject headings
- Alternative Splicing
- Chromatin Assembly and Disassembly
- Histones
- RNA Precursors