Impaired virulence and in vivo fitness of colistin-resistant Acinetobacter baumannii.
basic_science · Level V
Where this comes from
- Record sourced from PubMed, PMID 21216865.
- Also identified by DOI 10.1093/infdis/jiq086 and PMC identifier 3071218.
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Abstract
Acinetobacter baumannii (American Type Culture Collection strain 19606) acquires mutations in the pmrB gene during the in vitro development of resistance to colistin. The colistin-resistant strain has lower affinity for colistin, reduced in vivo fitness (competition index, .016), and decreased virulence, both in terms of mortality (0% lethal dose, 6.9 vs 4.9 log colony-forming units) and survival in a mouse model of peritoneal sepsis. These results may explain the low incidence and dissemination of colistin resistance in A. baumannii in clinical settings.
Medical subject headings
- Acinetobacter Infections
- Acinetobacter baumannii
- Anti-Bacterial Agents
- Colistin
- Drug Resistance, Bacterial