Roles and mechanisms of microRNAs in pancreatic cancer.
review · Level V
Where this comes from
- Record sourced from PubMed, PMID 21222121.
- Also identified by DOI 10.1007/s00268-010-0952-z and PMC identifier 3275100.
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Abstract
Pancreatic cancer (PC) is an aggressive malignancy with poor survival. The discovery of microRNAs (miRNAs) has provided a new opportunity to study the disease. Thus far, altered expression of miRNAs has been reported in a wide range of malignancies, including PC, and some miRNAs are associated with PC cell proliferation, invasion, chemoresistance, and patient survival. This review summarizes recent advances with respect to the roles and mechanisms of miRNAs in PC and discusses potential clinical applications.
Medical subject headings
- MicroRNAs
- Pancreatic Neoplasms