Fueling the fire in acute kidney injury: endothelial cells collect their Toll.
editorial · Level V
Where this comes from
- Record sourced from PubMed, PMID 21228799.
- Also identified by DOI 10.1038/ki.2010.456 and PMC identifier 3086207.
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Abstract
Chen et al. demonstrate endothelial expression of Toll-like receptor 4 (TLR4) in the outer medulla of the kidney early in the course of ischemic acute kidney injury. Furthermore, they provide data that support the hypothesis that activation of endothelial TLR4 in the early extension phase of AKI by damage-associated molecular pattern molecules released from injured tubules results in endothelial activation. This activation can serve to amplify inflammation and tubular damage.
Medical subject headings
- Acute Kidney Injury
- Endothelial Cells
- Ischemia
- Kidney
- Toll-Like Receptor 4