Angiotensin II: breathtaking in the renal medulla.
basic_science · Level V
Where this comes from
- Record sourced from PubMed, PMID 21228800.
- Also identified by DOI 10.1038/ki.2010.434 and PMC identifier 3621768.
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Abstract
Angiotensin II (Ang II) is a major contributor to the progression of renal fibrosis. Wang and colleagues provide evidence that signaling through the prolyl-4-hydroxylase domain (PHD)-hypoxia-inducible factor-1 (HIF-1) pathway mediates profibrotic effects of Ang II in rat renal medullary interstitial cells under normoxic conditions, thus placing the HIF oxygen-sensing pathway into the center of an Ang II-induced profibrotic signaling cascade.
Medical subject headings
- Angiotensin II
- Hypoxia-Inducible Factor 1, alpha Subunit
- Kidney Medulla