Antinuclear antibodies and clinical associations in a british cohort with limited cutaneous systemic sclerosis.
cross_sectional · Level IV
Where this comes from
- Record sourced from PubMed, PMID 21239752.
- Also identified by DOI 10.3899/jrheum.100754.
- No licence information is recorded for this record.
- Because redistribution is not established, this page shows the abstract only. Follow the links below for the full text.
Abstract
To assess the prevalence of disease-specific autoantibodies in patients with limited cutaneous systemic sclerosis (lcSSc). Sera from 180 patients with lcSSc were analyzed for antinuclear antibody (ANA). Clinical characteristics were compared in the presence or absence of specific autoantibodies. SSc-specific antibodies were detected in 135 patients (75%). Associations were found between anticentromere antibody and age at lcSSc diagnosis, telangiectasia, reduced creatinine clearance, and selective reduction in DLCO, and between antitopoisomerase-I and pulmonary fibrosis. The majority of patients with lcSSc belong to distinctive serologic subsets, potentially with prognostic significance.
Medical subject headings
- Antibodies, Antinuclear
- Scleroderma, Limited