Nanotopographic control of neuronal polarity.
basic_science · Level V
Where this comes from
- Record sourced from PubMed, PMID 21241061.
- Also identified by DOI 10.1021/nl103349s.
- No licence information is recorded for this record.
- Because redistribution is not established, this page shows the abstract only. Follow the links below for the full text.
Abstract
We employ simple geometrical rules to design a set of nanotopographies able to interfere with focal adhesion establishment during neuronal differentiation. Exploiting nanoimprint lithography techniques on cyclic-olefin-copolymer films, we demonstrate that by varying a single topographical parameter the orientation and maturation of focal adhesions can be finely modulated yielding independent control over the final number and the outgrowth direction of neurites. Taken together, this report provides a novel and promising approach to the rational design of biocompatible textured substrates for tissue engineering applications.
Medical subject headings
- Cell Culture Techniques
- Nanostructures
- Nanotechnology
- Neurons
- Tissue Engineering