Are polycomb group bodies gene silencing factories?
basic_science · Level V
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- Record sourced from PubMed, PMID 21241887.
- Also identified by DOI 10.1016/j.cell.2011.01.006.
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Abstract
Polycomb group (PcG) proteins mediate long-range associations between Hox genes, which correlate with gene repression in vivo. Bantignies et al. (2011) identify a physiological role for the nuclear localization of Hox genes in PcG-mediated gene silencing, strengthening the evidence that nuclear positioning regulates gene expression.