Rallying the exocyst as an autophagy scaffold.
basic_science · Level V
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- Record sourced from PubMed, PMID 21241888.
- Also identified by DOI 10.1016/j.cell.2011.01.005 and PMC identifier 3030914.
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Abstract
Protein scaffolds coordinate the assembly of many multicomponent signaling complexes. Bodemann et al. (2011) now show that the exocyst, a protein complex involved in tethering transport vesicles to the plasma membrane, provides an assembly and activation platform for components of the autophagy machinery via a process requiring the GTPase RalB.