Diversity-oriented synthesis leads to an effective class of bifunctional linchpins uniting anion relay chemistry (ARC) with benzyne reactivity.
basic_science · Level V
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- Record sourced from PubMed, PMID 21245309.
- Also identified by DOI 10.1073/pnas.1015265108 and PMC identifier 3084103.
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Abstract
In conjunction with the construction of a diversity-oriented synthesis library of 10-membered ring "natural product-like" macrolides, the design, synthesis, and validation of a unique class of bifunctional linchpins, uniting benzyne reactivity initiated by type II anion relay chemistry (ARC) has been achieved, permitting access to diverse [2+2], [3+2], and [4+2] cycloadducts.
Medical subject headings
- Benzene Derivatives
- Macrolides