Contribution of platelets to tumour metastasis.
review · Level V
Where this comes from
- Record sourced from PubMed, PMID 21258396.
- Also identified by DOI 10.1038/nrc3004 and PMC identifier 6894505.
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Abstract
Extensive experimental evidence shows that platelets support tumour metastasis. The activation of platelets and the coagulation system have a crucial role in the progression of cancer. Within the circulatory system, platelets guard tumour cells from immune elimination and promote their arrest at the endothelium, supporting the establishment of secondary lesions. These contributions of platelets to tumour cell survival and spread suggest platelets as a new avenue for therapy.
Medical subject headings
- Blood Platelets
- Neoplasm Metastasis
- Platelet Activation