LINGO1 variants in the French-Canadian population.
case_control · Level III
Where this comes from
- Record sourced from PubMed, PMID 21264305.
- Also identified by DOI 10.1371/journal.pone.0016254 and PMC identifier 3019170.
- Licence recorded as CC BY.
- The licence permits redistribution, so the abstract is shown in full and the full text is available from the publisher.
Abstract
Essential tremor (ET) is a complex genetic disorder for which no causative gene has been found. Recently, a genome-wide association study reported that two variants in the LINGO1 locus were associated to this disease. The aim of the present study was to test if this specific association could be replicated using a French-Canadian cohort of 259 ET patients and 479 ethnically matched controls. Our genotyping results lead us to conclude that no association exists between the key variant rs9652490 and ET (P(corr) = 1.00).
Medical subject headings
- Essential Tremor
- Genome-Wide Association Study
- Membrane Proteins
- Nerve Tissue Proteins
- Polymorphism, Single Nucleotide