Potent engineered PLGA nanoparticles by virtue of exceptionally high chemotherapeutic loadings.
basic_science · Level V
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- Record sourced from PubMed, PMID 21265552.
- Also identified by DOI 10.1021/nl104117p and PMC identifier 3122105.
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Abstract
Herein we report the fabrication of engineered poly(lactic acid-co-glycolic acid) nanoparticles via the PRINT (particle replication in nonwetting templates) process with high and efficient loadings of docetaxel, up to 40% (w/w) with encapsulation efficiencies >90%. The PRINT process enables independent control of particle properties leading to a higher degree of tailorability than traditional methods. Particles with 40% loading display better in vitro efficacy than particles with lower loadings and the clinical formulation of docetaxel, Taxotere.
Medical subject headings
- Crystallization
- Lactic Acid
- Nanocapsules
- Polyglycolic Acid
- Taxoids