Crystallographic observation of 'induced fit' in a cryptophane host-guest model system.
basic_science · Level V
Where this comes from
- Record sourced from PubMed, PMID 21266998.
- Also identified by DOI 10.1038/ncomms1151 and PMC identifier 3105606.
- Licence recorded as CC BY-NC-SA.
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Abstract
Cryptophane-A, comprised of two cyclotriguaiacylenes joined by three ethylene linkers, is a prototypal organic host molecule that binds reversibly to neutral small molecules via London forces. Of note are trifunctionalized, water-soluble cryptophane-A derivatives, which exhibit exceptional affinity for xenon in aqueous solution. In this paper, we report high-resolution X-ray structures of cryptophane-A and trifunctionalized derivatives in crown-crown and crown-saddle conformations, as well as in complexes with water, methanol, xenon or chloroform. Cryptophane internal volume varied by more than 20% across this series, which exemplifies 'induced fit' in a model host-guest system.