Codon adaptation-based control of protein expression in C. elegans.
basic_science · Level V
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- Record sourced from PubMed, PMID 21278743.
- Also identified by DOI 10.1038/nmeth.1565.
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Abstract
We present a method to control protein levels under native genetic regulation in Caenorhabditis elegans by using synthetic genes with adapted codons. We found that the force acting on the spindle in C. elegans embryos was related to the amount of the G-protein regulator GPR-1/2. Codon-adapted versions of any C. elegans gene can be designed using our web tool, C. elegans codon adapter.
Medical subject headings
- Caenorhabditis elegans
- Caenorhabditis elegans Proteins
- Codon
- Gene Expression Regulation
- Genetic Techniques
- Protein Biosynthesis