Raging hormones: gender and renal disease.
basic_science · Level V
Where this comes from
- Record sourced from PubMed, PMID 21278778.
- Also identified by DOI 10.1038/ki.2010.474.
- No licence information is recorded for this record.
- Because redistribution is not established, this page shows the abstract only. Follow the links below for the full text.
Abstract
Gender affects the progression of renal disease. In a variety of animal models and in certain human renal diseases, females exhibit a more modest course of kidney disease. Estrogens and testosterone have been implicated in this gender disparity. Doublier and colleagues explore the direct effects of sex hormones on podocyte viability in the α-estrogen receptor knockout (αERKO) mouse. They report that testosterone induces, and estradiol inhibits, podocyte damage in this model.
Medical subject headings
- Gonadal Steroid Hormones
- Kidney Diseases