Nanoengineered surfaces enhance drug loading and adhesion.
basic_science · Level V
Where this comes from
- Record sourced from PubMed, PMID 21280638.
- Also identified by DOI 10.1021/nl103951e and PMC identifier 3053427.
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Abstract
To circumvent the barriers encountered by macromolecules at the gastrointestinal mucosa, sufficient therapeutic macromolecules must be delivered in close proximity to cells.(1) Previously, we have shown that silicon nanowires penetrate the mucous layer and adhere directly to cells under high shear.(2) In this work, we characterize potential reservoirs and load macromolecules into interstitial space between nanowires. We show significant increases in loading capacity due to nanowires while retaining adhesion of loaded particles under high shear.
Medical subject headings
- Cell Adhesion
- Nanotechnology
- Pharmaceutical Preparations