Polymorphic allele of human IRGM1 is associated with susceptibility to tuberculosis in African Americans.
case_control · Level III
Where this comes from
- Record sourced from PubMed, PMID 21283700.
- Also identified by DOI 10.1371/journal.pone.0016317 and PMC identifier 3025014.
- Licence recorded as CC BY.
- The licence permits redistribution, so the abstract is shown in full and the full text is available from the publisher.
Abstract
An ancestral polymorphic allele of the human autophagy-related gene IRGM1 is associated with altered gene expression and a genetic risk for Crohn's Disease (CD). We used the single nucleotide polymorphism rs10065172C/T as a marker of this polymorphic allele and genotyped 370 African American and 177 Caucasian tuberculosis (TB) cases and 180 African American and 110 Caucasian controls. Among African Americans, the TB cases were more likely to carry the CD-related T allele of rs10065172 (odds ratio of 1.54; 95% confidence interval, 1.17-2.02; P<0.01) compared to controls. Our finding suggests that this CD-related IRGM1 polymorphic allele is also associated with human susceptibility to TB disease among African Americans.
Medical subject headings
- Black or African American
- GTP-Binding Proteins
- Genetic Predisposition to Disease
- Polymorphism, Single Nucleotide
- Tuberculosis