AMPK-dependent phosphorylation of ULK1 induces autophagy.
basic_science · Level V
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- Record sourced from PubMed, PMID 21284977.
- Also identified by DOI 10.1016/j.cmet.2011.01.009 and PMC identifier 3056410.
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Abstract
AMP-activated protein kinase (AMPK) is a highly conserved cellular energy sensor that plays a central role in metabolic homeostasis. A recent study in Science (Egan et al., 2011) identifies ULK1 as a substrate for AMPK phosphorylation, a modification required for selective autophagy of mitochondria and cell survival during starvation.