Biological mechanisms of chronic fatigue.
review · Level V
Where this comes from
- Record sourced from PubMed, PMID 21285230.
- Also identified by DOI 10.1093/rheumatology/keq454.
- No licence information is recorded for this record.
- Because redistribution is not established, this page shows the abstract only. Follow the links below for the full text.
Abstract
Chronic fatigue is a common, poorly understood and disabling phenomenon in many diseases. We aim to provide an overview of fatigue in chronic autoimmune and inflammatory disease. Fatigue measurement, prevalence and confounding factors such as depression, sleep disorders and pain are reviewed in the first half of the article. In the second half of the article, we describe explanatory models of fatigue and fatigue signalling, with an emphasis on cytokines and sickness behaviour, oxidative stress, mitochondrial dysfunction and the impact of certain genes on fatigue.
Medical subject headings
- Cytokines
- Fatigue
- Genetic Predisposition to Disease
- Oxidative Stress