Lack of detectable HIV-1-specific CD8(+) T cell responses in Zambian HIV-1-exposed seronegative partners of HIV-1-positive individuals.
other · Level V
Where this comes from
- Record sourced from PubMed, PMID 21288826.
- Also identified by DOI 10.1093/infdis/jiq028 and PMC identifier 3071055.
- Licence recorded as CC BY-NC.
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Abstract
Human immunodeficiency virus type 1 (HIV-1)-specific T cell responses were characterized in a blinded study involving infected individuals and their seronegative exposed uninfected (EU) partners from Lusaka, Zambia. HIV-1-specific T cell responses were detected ex vivo in all infected individuals and amplified, on average, 27-fold following in vitro expansion. In contrast, no HIV-1-specific T cell responses were detected in any of the EU partners ex vivo or following in vitro expansion. These data demonstrate that the detection of HIV-1-specific T cell immunity in EU individuals is not universal and that alternative mechanisms may account for protection in these individuals.
Medical subject headings
- CD8-Positive T-Lymphocytes
- HIV Infections
- HIV-1
- Sexual Partners